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Vitamin C and the Common Cold – Retrospective Analysis of Chalmers’ Review

J Am Coll Nutr. 1995 Apr;14(2):116-23.

Vitamin C and the Common Cold: a Retrospective Analysis of Chalmers’ Review.

Hemilä H1, Herman ZS.
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In 1975 Thomas Chalmers analyzed the possible effect of Vitamin C on the common cold by calculating the average difference in the duration of cold episodes in Vitamin C and control groups in seven placebo-controlled studies.

He found that episodes were 0.11 +/- 0.24 (SE) days shorter in the Vitamin C groups and concluded that there was no valid evidence to indicate that Vitamin C is beneficial in the treatment of the common cold.

Chalmers’ review has been extensively cited in scientific articles and monographs. However, other reviewers have concluded that Vitamin C significantly alleviates the symptoms of the common cold.

A careful analysis of Chalmers’ review reveals serious shortcomings.

For example, Chalmers did not consider the amount of Vitamin C used in the studies and included in his meta-analysis was a study in which only 0.025-0.05 g/day of Vitamin C was administered to the test subjects.

For some studies Chalmers used values that are inconsistent with the original published results.

Using data from the same studies, we calculated that Vitamin C (1-6 g/day) decreased the duration of the cold episodes by 0.93 +/- 0.22 (SE) days; the relative decrease in the episode duration was 21%.

The current notion that Vitamin C has no effect on the common cold seems to be based in large part on a faulty review written two decades ago.

Comment in:
Vitamin C supplements and disease–counterpoint. [J Am Coll Nutr. 1995]
PMID: 7790685

[Indexed for MEDLINE]

US National Library of Medicine – National Institutes of Health

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